Bioactive Small Molecules
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Filtered Search Results
Abcam TAPI-2, MMP and ADAM inhibitor, 1MG
MW 415.5 Da, Purity >95%. Broad spectrum inhibitor of TACE (TNF-α convertase/ADAM17/α-secretase), MMPs and other ADAMs. Blocks phorbol-12-myristate-13-acetate-induced (PMA) shedding of cell surface proteins such as TGF-α and β-amyloid precursor protein (IC₅₀ = 10 μM). Inhibits TNF-α release.
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Abcam RO 20-1724, Phosphodiesterase 4 (PDE4) inhibitor, 50MG
MW 278.35 Da, Purity >99%. Selective cAMP-specific phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 3 μM). Centrally active in vivo.
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Abcam Naftopidil hydrochloride, alpha1 Adrenoceptor antagonist, 50MG
MW 428.96 g/mol, Purity >98%. α₁ Adrenoceptor antagonist. pKi values are 3.7, 20 and 1.2 for α₁a, α₁b and α₁d, respectively. Orally active. Implicated in benign prostate hyperplasia and bladder obstruction. Antihypertensive.
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Cayman Chemical ANTIBODY FlumazenIl 100mg
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A GABAA receptor antagonist (IC50 = 2 nM in a radioligand binding assay using rat cortical synaptosomes); decreases the amplitude of electrically stimulated population spikes in rat hippocampal CA1 pyramidal neurons; increases the number of entries into the open arms of the elevated plus maze in BALB/c, but not C57BL/6, mice from 0.1-1,000 UG/kg; prevents allopregnanolone-induced reduction of burying behavior in ovariectomized rats at 5 and 10 mg/kg
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Cayman Chemical SB 277011AhydrochlorIde 5mg
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A selective antagonist of the dopamine D3 receptor (pKi = 8.0); has high oral bioavailability and enters the central nervous system of the rat
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Cayman Chemical ANTIBODY VER-50589 1mg
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An isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM; produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel
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Cayman Chemical ProstaglndIn D1 5mg
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An inhibitor of platelet aggregation (IC50 = 320 ng/ml in human platelet-rich plasma)
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Cayman Chemical NtrIdecnoylLHomoserIn la 5mg
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An N-acyl homoserine lactone; has been found in Y. pseudotuberculosis
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Cayman Chemical ApelIn13trIfluoroacetAT s 5mg
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Endogenous ligand of the APJ receptor, with an EC50 of 0.37 nM; acts primarily in the periphery and CNS, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity
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Cayman Chemical trns-Resveratrol-3-OD-Glu 1mg
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A stilbene and an active metabolite of trans-resveratrol; binds to COX-1 (IC50 = 150 µM); reduces the proliferation of several intestinal cancer cell lines (IC50s = 10-16.5 µM) and induces cell cycle arrest in SW480 cells at 30 µM; increases pyruvate production in livers isolated from rats in a model of CFA-induced arthritis at 200 µM
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AdipoGen 6-Amino-D-luciferin
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Chemical. CAS 161055-47-6. Formula C11H9N3O2S2. MW 279.34. Synthetic. Amino analog of the common D-luciferin substrate for use in measuring firefly luciferase activity. This cell permeable reagent can be used when considering design of proluminescent bioconjugates peptidase substrates of luciferin for ultrasensitive luminescent assays. In bioluminescent protease assays peptides or amino acids are conjugated to the luciferin analog 6-amino-D-luciferin. These substrates are useful for ultrasensitive analysis of a variety of protease enzymes including various caspases and cathepsins, chymotrypsin, trypsin, elastase, kallikrein, thrombin, ficin, bromoalain, plasmin, papain, ficin and many others or even for use in vivo tracing of luciferase transfected cells in living tissues. The resulting bioluminescence spectrum of reaction of 6-Amino-D-luciferin is very similar to that observed for the natural substrate D-luciferin.
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Cayman Chemical ANTIBODY ZInpyr-1 1mg
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A cell-permeable, fluorescein-based probe for zinc detection; undergoes a shift in excitation from 515 to 507 nm with increasing zinc concentrations using an emission filter over 513-558 nm
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Cayman Chemical ANTIBODY CAY10683 50mg
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A potent HDAC inhibitor that inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM; ineffective against HDAC4 (IC50 = >1,000 nM); inhibits the growth of HCT116 cells and HuT-78 cells (GI50 = 29.4 and 1.4 μM, respectively) more effectively than human dermal fibroblasts (GI50 = >100 μM)
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TRILINK BIO TECHNOLOGIES INC ENGINEERED RNASE INHIBITOR
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NC3457312 ENGINEERED RNASE INHIBITOR
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GENOVIS INC INHIBITOR THERMOSTABLE 3X150
NC3500479 INHIBITOR THERMOSTABLE 3X150
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